How CDC is using science to learn more about post-COVID conditions (or long COVID)
For the General Public: Long COVID (Post-COVID Conditions)
CDC is analyzing healthcare data, partnering with clinicians, and working with researchers to learn more about post-COVID conditions (Long COVID).
Post-COVID conditions (PCC, or Long COVID) are a wide range of new, returning, or ongoing health problems people can experience four or more weeks after first being infected with the virus that causes COVID-19.
CDC and partners are doing research on post-COVID conditions in a variety of populations and settings. These partnerships are essential for expanding the base of evidence needed for addressing post-COVID conditions. CDC and its partners are working to:
MMWR COVID-19 ReportsCDC Scientific Publications on COVID-19
CDC and partners are collecting and analyzing information about post-COVID conditions and health problems through several public health activities, including
Inclusion of data and analyses of post-COVID conditions by race/ethnicity, age, sex, and other factors are a CDC priority.
Select examples of research on post-COVID conditions conducted by CDC and partners
FindCOVID
Follows cases in children and adults infected with the virus that causes COVID-19 and their household members to measure initial clinical presentation, viral shedding, transmission, immune response, and on-going symptoms from the time of infection up to 12 months.
Population:  Children and adults
Partner: University of California, San Francisco (UCSF)
Immune Response to SARS-CoV-2 among patients in Louisiana
Follows cases in patients recovering from COVID-19 to assess longer term clinical and immunity related outcomes up to one year after the beginning of the illness. Follows a subgroup of cases in COVID-19 patients hospitalized for severe COVID-19 illness for one year following hospital admission.
Population: Adults, with a focus on persons at higher risk for severe COVID-19
Partner: Tulane University School of Medicine, Infectious Diseases
Applied Research to Address the Coronavirus (COVID-19) Emerging Public Health Emergency
Follows cases in participants who report on daily symptoms, testing, care seeking, and vaccination. Conducts monthly testing for antibodies to the virus that causes COVID-19 and analysis of electronic health records to assess ongoing clinical diagnoses, for a minimum of six months.
Population: Adults identified by the University of Maryland and Medstar Health in the mid-Atlantic area, Wake Forest University and Atrium Health System in the North Carolina area, Tulane University, and the University of Mississippi
Partner: COVID-19 Community Research Partnership, Vysnova Partners
COVID-19 within American Indian Communities at High Risk in the Southwest U.S.
Follows people who are infected with the virus that causes COVID-19 for up to 12 months to assess the development and duration of symptoms, complications from infection, and immune response over time.
Population: Navajo and White Mountain Apache communities
Partner: Johns Hopkins University, Bloomberg School of Public Health, Center for American Indian Health
Longitudinal Study of COVID-19 Antibody Response in Children in Seattle, WA
Follows cases in children and adolescents (up to 18 years old) who test positive for the virus that causes COVID-19, to assess the development and duration of the immune response, symptoms, and complications over time, for up to two years.
Population: Children and adolescents
Partner: University of Washington; Seattle Children’s Hospital
COVID: Research on COVID Long-Term Illness, Effects, and Risk Factors (COVID-RELIEF)
Tracks electronic health records of patients who test positive and negative for the virus that causes COVID-19 and documents symptoms and medical conditions for an average of 2 years after infection. A subgroup of patients who previously tested positive for COVID-19 provides self-reported data on health and biospecimens to investigate genetic and other risk factors for delayed recovery.
Population: Adults receiving care in a university health system
Partner: University of Washington, Seattle, WA
COVID-19: Understanding the Post-Viral Phase (COVID-UPP)
Assesses participants’ health over time using surveys and, for a subset of participants, using physical exams and medical tests to compare differences and similarities with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Adults who tested positive for the virus that causes COVID-19 and continue to have symptoms more than three months after infection are compared with those who fully recovered.
Population: Adults, with a focus on Hispanic or Latino persons who tested positive for the virus that causes COVID-19 and continue to have symptoms more than three months after infection
Partner: Nova Southeastern University, Fort Lauderdale, FL
Support for Patients With SARS-CoV-2 Infections Registry (INSPIRE)
Follows cases in adults who test positive for COVID-19 and a comparison group of adults who test negative for SARS-CoV-2 every 3 months for up to 18 months. Participants complete detailed surveys, including information on social determinants of health, and provide linked electronic health information.
Population: Adults tested for SARS-CoV-2 infection
Partners: Rush University, Yale University, Jefferson Medical, University of Washington, UCLA, UCSF, UT Southwestern, UT Houston
COVIDStandardized Evaluation of Long-term Effects (COVID-SELECT)
Collects information from patients at risk of or who have post-COVID conditions about their health through online questionnaires, with follow up on their health one year later. Information will be used to identify and describe those who have long-term symptoms after having COVID and whose results on routine medical tests and physical examination are normal.
Population: Adults from a demographically diverse population receiving care in a large, integrated health system in northern and central California
Partners: Public Health Foundation Enterprises, Inc.; California Emerging Infections Program; Kaiser Permanente Northern California, Oakland, CA
Multi-Site Study of Post-COVID Conditions (MPCC)
Collects health data to describe the health and medical care of patients at clinics designed for post-COVID care to help classify types of post-COVID health problems and care needed and highlight unmet needs for care in other medical settings.
Population: Adult patients receiving care in post-COVID clinics at participating medical centers through September 30, 2021
Partners: Rainmaker Strategic Solutions, LLC; University of Texas Southwestern Medical Center; Dallas, TX; Creighton University Medical Center, Omaha, NE; Mt. Sinai Health System, New York, NY
Post-COVID Conditions among Patients Seen in Outpatient Settings – American Family Cohort
Analyzes electronic health record data from COVID-19 patients seen at over 800 primary care and family medicine practices to assess frequency of new symptoms and conditions among patients with COVID-19 diagnosis compared with patients with other respiratory diagnoses. Study will assess post-COVID conditions by race/ethnicity, age, sex, geography (urban/rural), and indices of social vulnerability.
Population: Children and adults
Partner: American Board of Family Medicine; Stanford University Center for Population Health Sciences
Post-COVID Conditions among Patients Seen in Outpatient and Inpatient Settings – PCORnet
Analyzes electronic health record data from COVID-19 patients seen in ambulatory, emergency department, and hospital settings in 40 U.S. healthcare systems to assess frequency of new symptoms and conditions among patients who tested positive for the virus that causes COVID-19 compared with patients who tested negative.
Population: Children and adults
Partner: PCORnet, the National Patient-Centered Clinical Research Network
Frequency of and Risk Factors for Post-COVID Conditions – Various Healthcare Data Sources
Analyzes several large healthcare data sources to provide estimates of new symptoms and conditions following COVID-19 diagnosis in outpatient and inpatient settings by patient demographic and clinical characteristics.
Population: Children and adults
Data Sources: Cerner HealtheDataLab, HealthVerity, Premier Healthcare Database Special COVID-19 Release
National Health Interview Survey
Collects information about symptoms of post-COVID conditions through a cross-sectional household survey to estimate the national prevalence of post-COVID conditions.
Population:  Adults and children
Data Source: National Center for Health Statistics, CDC
Behavioral Risk Factor Surveillance System
Collects information about symptoms of post-COVID conditions through a survey to produce state/territorial-level estimates of prevalence.
Population: Adults
Data Source: National Center for Chronic Disease Prevention and Health Promotion, CDC; participating state and territorial health departments
Multi-state Long Covid Survey
Surveyed adults who tested positive for SARS-CoV-2 for self-reported acute and post-COVID symptoms lasting four weeks or more to estimate prevalence of post-COVID conditions and identify demographic and disease-specific risk factors for developing post-COVID conditions.
Population: Adults who tested positive for the virus that causes COVID-19 in Maine, Wisconsin, New York, and New Jersey
Partners:  State health departments
Long COVID and Fatiguing Illness Recovery Program (LC&FIRP)
Evaluates whether educational interventions for primary healthcare providers through a distance-learning platform improves health outcomes of patients with post-COVID conditions and other complex chronic conditions with similar symptoms, such as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and other post-infectious fatiguing illnesses.
Population: Adults who are uninsured, with lower incomes, and who are medically underserved
Partners:  Family Health Centers of San Diego (FHCSD), San Diego, California; Project ECHO, Albuquerque, NM; University of Washington Post-COVID Clinic Rehabilitation and Recovery, Seattle, WA; University of Colorado, Denver, CO; ATA Health Strategies, Washington, DC
The National Institutes of Health (NIH) created the RECOVER Initiative, a research project that aims to understand how people recover from a COVID-19 infection and why some people do not fully recover and develop long COVID or post-acute sequelae of SARS-CoV-2 (PASC). Anyone can participate in the RECOVER project, including those who have COVID-19 now, had COVID-19 before, or never had COVID-19. People of all races and ethnicities, genders, ages, and locations will be included in the research project to better understand how long COVID affects people.
To learn more, including enrollment, visit the RECOVER webpage.
The purpose of COCA continuing education opportunities is to increase clinicians’ knowledge of threats to the public’s health and provide information on clinical evaluation management strategies to address these threats. COCA continuing education is free. Learn about receiving continuing education (CE) credit for COCA calls.
CDC is publishing the results of studies aimed at better understanding post-COVID conditions and how best to support people experiencing post-COVID conditions and health problems.
Select CDC publications on post-COVID conditions and related topics:
Prospective Cohort Studies

Analysis of Electronic Healthcare Data


Health Surveys


Electronic Medical Chart Abstraction


Commentary

To receive email updates about COVID-19, enter your email address:

source